Will the Stem Cell Ruling Affect Venture Capital Investing?

September 1, 2010 source: xconomy

Brad Webb, Venture Partner at Claremont Creek Ventures, was featured today on the xcononomy website discussing the implications for venture investment of the recent judicial ruling regarding federal funding for stem cell research.

Last week’s federal district court ruling ordering an immediate halt in federal funding for stem cell research has thrown academic research circles into a state of confusion. This has caught the attention of the VC community, as the venture-backed biotech world is largely dependent on technology developed in academic institutions, and the cutting-edge research produced by universities is crucially dependent on federal grant funding…

…The legal system and historians will have to decide. But the episode illustrates that the federal government continues to be an engine of unintended consequences. In this case, depending on NIH funding turned out to be a risky financing strategy for university research departments. This fact will surely alter the calculations of venture firms and biotech industry executives, for whom risk assessment is a constant chore. Investors hate uncertainty—and the questions created by the constantly shifting legal landscape surrounding stem cell research pervade the medical technology industries today.

[read the full article at xconomy]

Brad’s opinion piece at xconomy was covered by the Wall Street Journal and Med City News

Will Thermoelectric Servers Power Greener Data Centers?

August 17, 2010 source:Gigaom

Most of the recent research into thermoelectrics has centered around using nanotechnology to design thermoelectric materials that conduct electricity but not heat. In March, researchers at Boston College and MIT announced that they had achieved a major thermoelectric efficiency increase in bismuth telluride by breaking it down and “rebuilding it in a composite of nanostructures in bulk form,” according to Boston College physicist Zhifeng Ren.

Other startups appear to be pursuing similar nanotechnology routes to more efficient thermoelectric devices. In May, Lawrence Berkeley National Laboratory spin-out Alphabet Energy landed a seed round of $1 million from Claremont Creek Ventures and the CalCEF Clean Energy Angel Fund to work on its thermoelectric materials, which it claims will be 50 times cheaper than existing materials, bringing its power generating costs to around $1 per watt. …

Micah Myers will be a VC panelist at Cleantech VC Pitch

The Cleantech VC Pitch

August 30, 2010 | 6:00-8:30 PM
650 Page Mill Road, Palo Alto
Event Sponsor: Wilson Sonsini Goodrich & Rosati
[ click for more information or to register for the event ]

Micah Meyers

The Cleantech VC Pitch program through VC Taskforce offers an opportunity for entrepreneurs seeking start up funding to pitch in front of a distinguished panel of investors whose investment focus is cleantech. The evening will be exciting and a terrific learning experience for all entrepreneurs. Entrepreneurs learn what VCs are looking for in a pitch presentation.

Entrepreneurs seeking capital will have 2 minutes to give their best Elevator Pitch in front of the Cleantech VCs.

Fertility Patients Can Now Use One Screening for Multiple Types of Genetic Diseases Before Pregnancy

August 10, 2010 source: Send2Press Newswire

DAVIS, Calif., Aug. 10 (SEND2PRESS NEWSWIRE) — California IVF: Davis Fertility Center, Inc. (californiaivf.com), working in conjunction with Gene Security Network (genesecurity.net) leads the field in bringing a new test to patients that combines the detection of single-gene genetic disorders with a 24 chromosome screening.

Using Gene Security Network’s Parental Support™ technology, at-risk couples undergoing in vitro fertilization can now test developing embryos for a larger number of hereditary diseases before implantation and pregnancy. This pre-implantation genetic screening/diagnosis (PGD/PGS) tests for single gene disorders like Sickle Cell and chromosomal abnormalities like Down Syndrome with a single cell from each embryo. This is the first commercial application of these combined screenings.

GSN’s proprietary Parental Support(TM) technology is the first to leverage data informatics to deliver highly accurate single cell testing for chromosome abnormalities and genetic diseases. The company is based in Redwood City, CA, and supported by multiple grants from the National Institutes of Health and leading venture investors like Claremont Creek Ventures and Sequoia Capital. GSN’s technology is at the forefront of pre-implantation genetic testing and the demand for their services has been increasing rapidly. For more information, please visit PGD Experts or www.genesecurity.net. [Read more ...]

Shout Out About Ted Driscoll in Huffington Post: Taking Time to Help Entrepreneurs

August 9, 2020 source: The Huffington Post: The Language of Venture Capital by Michele Colucci

The first time I attended a conference to learn about venture, I was greeted at the door by a man who said, simply, “VC or Entrepreneur?” I knew I wasn’t a “VC” or Venture Capitalist, but had never realized that I was an Entrepreneur — or that the word “Entrepreneur” could actually be a job title.

So, shortly thereafter, I joined the ASTIA program for female entrepreneurs (now firm in my conviction that I was an Entrepreneur). This is an incubator for female CEO’s with start-ups. I distinctly remember sitting in one of the first seminars struggling to follow the language one of the instructor/CEO’s was using to demonstrate how to assemble my company financials. It was then that I realized that almost every other woman in the room was struggling to keep up as well. Yes, there were a few MBA’s who had the lingo down, but not the rest of us. And what I also realized was, it wasn’t because we weren’t able to articulate what was being asked of us — in fact, most of us could rattle off the answers if asked in layman’s terms. But not so in venture speak.

Since that time, I’ve started to familiarize myself with the terminology necessary to operate in this world of start-ups, fundraising and building a business. It was not something that, as a woman, I had ever been exposed to, though I had started businesses before. And I realized that women in particular are very disadvantaged by not knowing this language.

So, for my first blog, I am sharing with my fellow female entrepreneurs what and how I learned the “language of venture.”

Here are a few suggestions that worked for me:

1. Attend pitch sessions. Most angel groups have showcases. (you can Google angel showcase in your area; or if you don’t find any, check out www.vator.com, the www.pitch.com or other online pitching opportunities. (Note: a “pitch” is exactly what it sounds like — you explain your idea in concise, clear language designed to let your potential investor see what you see in the idea with an end goal of getting them to give you money to do it.) I’d also suggest seeking the advice of others in the audience. If you’re lucky enough as I was to sit next to someone who will take the time to critique the pitches for you (my chance meeting was with Ted Driscoll, angel, VC and now friend extraordinaire…), then take advantage of the fact that most have probably seen hundreds of these pitch’s and can focus you on the most effective way to clearly and concisely present your business and connect with potential investors.

2. Earnings Calls: I got a great bit of advice from a friend at Goldman I met on a plane years ago. He said: Listen to earnings calls. Anyone can call in. So give it a try. Write down all the words you hear that you are not familiar with. Then look them up. Google them. See how they’re used. Then try to apply them to your business. If you pick up languages easily, great. If not, listen more. You’ll pick it up and soon start talking about your relationships in terms of scaling! (Or not… yikes… time to bail.)

3. Power Point: Do a tutorial for using the Power Point program. This is the common form of presentation when you pitch your idea to potential investors or venture folks. I have always liked Bill Reichert’s pitch guidelines. Aside from being a smart man (evidenced by the fact that he’s married to a very lovely and smart woman who’s also a lawyer and also a Michelle), his advice is solid. You can find his slideshow presentation here, which contains the ten things that should be in your presentation. And don’t be deterred when they ask you to make it “pretty.” I was so worried about insulting my audience that I had all very serious words and statistics on each page. I was told venture loves statistics that support your proposition that the market is huge and that they will make tons of money if they invest — so they don’t have to take your word for it. Wrong on the words. Right on the statistics. Venture folks don’t like to work too hard to get your point. If they do, you lose their interest. Think of it like dating: If you take one look at him and yell “check!” — it’s probably not going to be a match made in heaven.

4. Connect to Women Run Networks: There are several networks promoting women such as ASTIA, Girls in Tech, Catalyst. I started with ASTIA, which is an incubator. Sharon Vosmek, ASTIA CEO, throws out some pretty interesting statistics (i.e. only 4.3% of venture investments in 2006 had female CEO’s). Translation = opportunity! So find one in your area and connect. Aside from providing access to funding, these places teach you “investor speak.” This language includes crafting your pitch, assembling a team, identifying market statistics that prove people need/want what you’re offering, assembling credible financials to make profit projections (another blog on this another day… ), and possible exits (how will investors realize their profit). They also provide relationships with other CEO’s or with “coaches” who have experience in your field. Bottom line, it’s all about being able to effectively communicate in their language the need for what you’re selling in the market, that your particular solution is the answer, and explaining just how your opportunity will make your investors rich (… now that’s a language we can all understand).

Hopefully I’ve been able to shed a little light on the language barrier preventing many women from obtaining venture investment for their business. If you have more suggestions or funny venture speak stories, I’d love to hear them!

Inspire, Innovate, Illuminate,

Michele

The 10% Better Mousetrap Fallacy

While recently listening to a deal pitch-review, I watched a number of entrepreneurs selling “a better mousetrap”.  Although they  had some improvements in their technology- focused value proposition, they  failed to understand the inhibitions to adoption in the market.  I asked them to focus their attention on the inherent switching costs for customers who are choosing this new alternative solution to a business problem.  They did not understand what I meant.

Promax mouse trap

mouse trap

I call this “the 10% better mousetrap fallacy”.

Changing customer behavior is not an exact science. Switching costs to move to a new technology solution include process changes, retraining, supply chain impacts, documentation and plain old inertia.  In many cases, it’s just easier and more cost effective to keep using what’s worked before.  A new approach needs to offer an order of magnitude impact to get attention and traction. Sometimes this can be in acquisition cost or in operating efficiency over time.  It could also come indirectly– –as in increased synergy with  other processes or better leverage with suppliers.

New approaches to business needs also need to assessed against the overall priorities of the customer set. If a new solution has impact, but is 10th on a list of fifteen priorities, the adoption rate will be slow. Organizations tend to focus on their top 3-4 priorities and may never get to 10th.  Higher impact for them  are the high priority items. It’s easier to let the important,  but lower priority areas continue as is.

What’s an entrepreneur to do?  I suggest he or she build an order of magnitude impact into your value proposition.  Understand the decision priorities for your targeted customer segments.  Define your market entry segments as those where you have the largest impact and see the priority ranked in the “Top 3”  for the customer.  Using this strategy, the entrepreneur will have that super-duper mousetrap targeted at very likely adopters.

Startups Should Sing Out Of the Same Hymnal

August 2, 2010 source peHUB

In the South where I was raised, folks learned the advantages of “singing from the same hymnal”. The phrase stems from a religious context, but applies to company behavior in startups. I use this adage when coaching our young company teams on how to best operate. Fundamentally, it means combining the unique skills of a startup team to optimize execution.

It seems to me there are at least 3 ways to apply this adage to business – in words, actions and in timing.

Read more about what Randy has to say on about this at his original post on peHUB

Idea Flow

Recently, I’ve been hearing a lot about how the VC model is dead, and the venture capital industry is drying up. This is justified by the lack of conventional exits and liquidity events, meaning the venture capital funds can’t return cash to their investors. While we have clearly been going through a flat spot in IPOs, and the world of acquirers is reduced, I’m not sure that implies the industry is dead. I think its just going through a stretched out phase.

For that reason, institutional investors have been reducing their allocation for venture capital and fewer venture firms are raising new funds.

water fall photo by Hamed Saber

Therefore there is less money going into startups, but that doesn’t mean the VC model is dead, just scaled back.

At VC conferences, you see graphs of how much money is going into the funds, how much is being invested in early and late stage deals, how many deals are being done and how many exits are happening. Inside the fund meetings, there is always a lot of talk about this abstract VC concept called “Deal Flow”– how many deals are we seeing; are we seeing the best deals or the dregs; and how many are competitive deals where multiple funds are bidding up the price?   In the board rooms of our investments, we talk about “Cash Flow” and burn rates.

The discussion everywhere is about the flow of money from one place to another, and accumulating in the chosen few winners. It’s all about “Flow”.

I want to talk about another abstract measure of the venture capital business that I am calling “Idea Flow”. What is “Idea Flow”? Simplistically, it is the rate at which new ideas are being generated. And what is it a function of?

I believe ”Idea Flow” is partly a function of population growth, and the number of fresh minds entering society–take for example the number of college students graduating and entering the workforce. Each young mind is looking at the world with a fresh perspective.

In addition, “Idea Flow” is also a function of how far we have gone in digesting the last few major revolutions in our society. For example, the Internet has provided  frictionless communication at negligible cost– this is a revolution that is clearly still happening. When there are major revolutions percolating through society that haven’t been fully exploited yet, then the “Idea Flow” rate is enhanced.

Finally, “Idea Flow” is a function of whether sufficient resources are available to gestate these ideas. Maybe this is a slightly different concept, I’ll call it ”Manifest Idea Flow”. In other words, maybe just having an idea isn’t enough.

We also need to let the idea bloom, give it fertile ground to sprout or it’s meaningless.

Allowing the idea to bloom is about both financial resources, and our society’s openness to try out new ideas, and new approaches to problems.

I’m sure one can identify other contributors to the rate of “Idea Flow”. My point  is that basic “Idea Flow” is clearly still growing. The number of college graduates continues to rise each year, and the population continues to grow. Additionally, we have experienced at least three major revolutions in the past few decades that are still playing themselves out:

  1. Information Technology (computers, memory, programming, AI)
  2. Biotechnology (genome mapping, molecular biochemistry, synthetic biology)
  3. Communication Technology (the Internet, email, texting, cellphones)

These are three general categories of revolution in process. And where they overlap, “Idea Flow” is even further enhanced.

I believe “Idea Flow” is the bedrock of the venture business. Without ideas, nothing can be created. You might as well buy Ma Bell and cash your dividend checks quarterly. The venture capital business starts with a couple of motivated entrepreneurs, a problem that needs solving and an idea.

In this time of economic turmoil, where cash flow and economic growth and investment capital are down substantially, the bedrock of the venture capital business is still healthy. If anything the current turmoil makes aspects of our economy more ripe for disruption. If the old ways are broken, let’s try a new way.

A larger number of bright young minds are emerging each year, and the ground is fertile. And today it often takes less capital than ever before to manifest an idea.

So I’m bullish on the venture capital business right now. While others say it is dead or broken, I believe it is likely to be even more fertile in the coming few years.

Valuations are down and the potential for profit is therefore up. The markets are more vulnerable to disruption. Old models are hurting in the downturn, and new models will have a great opportunity as we emerge from this downturn.

And the public investor is always interested in an exciting story of the future realized. The IPO market in some form will reopen soon — it’s already showing signs in 2010. And large companies will emerge from this downturn with their existing market approaches damaged, and needing new ways to continue growth. They will be acquiring again.

In the end, this business is about “Idea Flow” and it’s still healthy.

“VCs Opened Their Wallets Wider In 2Q, But It’s All Relative”

Randy Hawks,  interviewed by reporter Tomio Geron for this article in the Wall Street Journal who believes that investors are more positive today.

While many investors say they still invest at the same pace during a downturn, investor psychology is a factor, and it has improved recently, said

Randy Hawks, managing director at Claremont Creek Ventures.

“Maybe there’s been some lubrication because everyone feels more confident about the exit environment,” Hawks said.

ShotSpotter hires Ralph Clark–man of action

Ralph Clark, the new CEO of one of my portfolio companies, security startup ShotSpotter, is a great fit for this already successful company. In a presentation at the company last week, he showed that he is the right man for the job.

As he was talking to the employees, he told them that he took the CEO position given his deep affinity for community, and he finds it both in Oakland, where he lives, and at ShotSpotter.  He impressed everyone in a very short period of time and all of us on the Board were especially happy to see how the crowd felt about him.

Clark was president and CEO of startup GuardianEdge and previously an investment banker.   At GuardianEdge, he oversaw both the company’s strategic direction and day-to-day operations leading to its recent acquisition by Symantec. Before that, he was VP of finance at Adaptec.

He likes decisive action, a must-do for a successful startup CEO.

“We all speak the same language,– and the currency I use is the currency you use,” he told the company gathering. “You and I decide what we will do and we will go do it, not just THINK about what we might do.”

In other words, he said, be decisive, and then stick to your guns. That is Clark’s history, and that’s what the successful team at ShotSpotter already does, especially its engineers and product developers. This was all a major draw for Clark.  I really like startup CEOs with spark, and I am especially proud that Ralph Clark joined ShotSpotter.